Important Information for Your Healthcare ProviderYou should talk with your healthcare provider prior to using this medication if you have:
- Heart disease
- High blood pressure (hypertension)
- Low blood pressure (hypotension)
- Congestive heart failure (CHF)
- Kidney problems, such as kidney failure (renal failure)
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Neupro and Pregnancy)
- Breastfeeding (see Neupro and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Rotigotine to learn more, including information on who should not use this patch.)
How Does It Work?Rotigotine belongs to a group of medications known as dopamine agonists. This means that it works much like dopamine, a naturally occurring brain chemical. It binds to dopamine receptors and stimulates them, much like natural dopamine would.
Dopamine deficiency, which is caused by a loss of dopamine-producing cells in certain parts of the brain, may be responsible for many of the symptoms of Parkinson's disease. By using a medication that acts like dopamine, such as rotigotine, some of the symptoms of Parkinson's disease may be relieved. Although it would make sense to give dopamine itself to treat Parkinson's disease, this does not work because dopamine cannot cross the blood-brain barrier to reach the brain. Rotigotine acts much like dopamine and is capable of crossing the blood-brain barrier, making it an ideal Parkinson's medication.
It is not exactly clear how rotigotine works for treating RLS, although it is thought that the drug's effectiveness for treating RLS is due to its dopamine-agonist properties.