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Rotigotine Dosage

What Is the Recommended Rotigotine Dosage for Restless Legs Syndrome?

The recommended starting dose of rotigotine for treating restless legs syndrome (RLS) is one 1 mg/24 hours patch applied once daily. If necessary, your healthcare provider may increase this amount by 1 mg/24 hours every week, up to a maximum of 3 mg/24 hours.

Stopping Rotigotine

Potentially dangerous withdrawal symptoms have been reported when medications like rotigotine have been stopped too quickly. Some of these withdrawal symptoms include:
  • Fever
  • Stiff, rigid muscles
  • Altered consciousness
  • Muscle breakdown (rhabdomyolysis)
  • Unstable heart rate or blood pressure.
To avoid withdrawal symptoms when stopping rotigotine, it is recommended to reduce the dosage slowly. For people using rotigotine for Parkinson's disease, reduce the dosage by 2 mg/24 hours every other day. For restless legs syndrome, the dosage should be reduced by 1 mg/24 hours every other day.

General Information on Using Rotigotine

Some considerations to keep in mind during treatment with rotigotine include the following:
  • Rotigotine is applied to the skin once daily. Make sure to take the old patch off before applying a new one.
  • Rotigotine can be worn on the front of the abdomen (stomach), thigh, upper arm, flank, hip, or shoulder. Avoid areas that are oily, irritated, damaged, or will be rubbed by tight clothing. Rotate the application sites such that you do not use the same exact spot twice within two weeks.
  • If you must apply the patch to a hairy area, shave the area at least three days before applying the patch.
  • Press on the patch firmly for about 30 seconds when applying it, as this helps it adhere better.
  • Rotigotine can be worn while swimming, showering, bathing, or exercising. However, do not expose rotigotine to excessive sunlight, saunas, or other heat sources.
  • Do not cut the patch or fold it sharply, as this may cause the medication to be released too quickly.
  • Do not flush a used patch, as it still contains some medication that can get into the water supply. Dispose of it by folding it in half on itself, returning it to its original pouch, and disposing of it out of the reach of children or pets.
  • If a patch falls off, simply apply a new patch to be worn for the rest of the day and change your patch as usual the next day. If the edges start to peel off, it is okay to tape them down with bandaging tape.
  • Make sure to change your patch at the same time each day to maintain an even level of the medication in your bloodstream.
  • For the medication to work properly, it must be used as prescribed. Do not stop using rotigotine suddenly, as withdrawal symptoms may occur.
  • If you are unsure about anything related to your dose of rotigotine, please talk with your healthcare provider or pharmacist. Do not stop using the drug without first discussing it with your healthcare provider.
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Rotigotine Transdermal Patch Information

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