Treatment for Restless Legs Syndrome (Cont.)

 
Narcotics
Narcotics are strong pain-relieving medications that are used for treatment of restless legs syndrome in severe cases or for those that do not respond to dopaminergics. Narcotics include:
 
  • Codeine
  • Propoxyphene
  • Oxycodone.
 
Narcotics are usually prescribed for their ability to induce relaxation and diminish pain. Side effects can include dizziness, nausea, vomiting, and the risk of addiction.
 
Benzodiazepines
Benzodiazepines are used as RLS treatment for those with mild or intermittent symptoms. Benzodiazepines include clonazepam and diazepam. Although benzodiazepines help patients obtain a more restful sleep, they do not fully alleviate RLS symptoms. It is important to note that benzodiazepines may cause daytime sleepiness and are not recommended for people with sleep apnea or for older people.
 
Anticonvulsants
Anticonvulsants are medications that are used to treat epilepsy. These medicines may also be used as treatment for RLS. Anticonvulsants include:
 
 
Anticonvulsants are considered when dopaminergics fail. They are most effective in people with daytime and evening symptoms, and in those who describe the unpleasant feelings in the legs as painful.

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Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD