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Horizant Warnings and Precautions

People with kidney disease should consult their healthcare provider before taking Horizant. Precautions and warnings also apply to people who are switching to Horizant from Neurontin or Gralise, as well as to women who are pregnant or breastfeeding. Because this medication may cause drowsiness, do not drive or operate any machinery until you know how it affects you.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Horizant™ (gabapentin enacarbil) if you have:
  • Depression
  • A history of suicidal thoughts or actions
  • Kidney disease, such as kidney failure (renal failure)
  • Cancer
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Horizant

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Make sure you know how Horizant affects you before driving or operating any machinery, as the medicine can cause drowsiness and dizziness.
  • In general, you should avoid alcohol while taking Horizant, due to the risk of increased drowsiness.
  • Horizant increases the risk of certain cancers in rats. It is not known if the drug also increases the risk of cancer in humans.
  • Horizant is not interchangeable with other forms of gabapentin, such as Neurontin® or Gralise™. If you switch from one gabapentin product to another, your dosage may need to be adjusted.
  • Let your healthcare provider know if you have kidney disease, as a lower Horizant dosage may be recommended.
  • For people taking the drug once a day, usually this medication can be stopped abruptly if necessary. For people taking it twice a day, the medication should be stopped gradually. Abruptly stopping this medication may increase the risk for seizures.


  • Horizant can react with other medications (see Horizant Drug Interactions).
  • This product is considered a pregnancy Category C medication. This means that it may not be safe for pregnant women, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of taking the drug during pregnancy (see Horizant and Pregnancy).
  • Horizant passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Horizant and Breastfeeding).
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Horizant Medication Information

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